![]() ![]() Flumazenil is a 1,4-benzodiazepine derivative that has a high affinity for the benzodiazepine binding site on the GABA receptor. 2įlumazenil is a benzodiazepine receptor antagonist FDA approved in 1992 for reversal of benzodiazepine overdose and postoperative sedation from benzodiazepine anesthetics. Of those involving only benzodiazepines, 731 (1.25 %) patients experienced a major outcome and 11 (0.01 %) died. In 2019, there were 58,430 total benzodiazepine exposures reported to US poison centers. ![]() However, some patients with large benzodiazepine ingestions may benefit from flumazenil administration to avoid intubation. Most patients requiring intubation after benzodiazepine overdose have ingested multiple sedating substances. Overall the complication rate with benzodiazepine overdose is low 1. Intoxications with benzodiazepines are generally well-tolerated but can cause prolonged coma. Flumazenil associated seizures require treatment with alternative agents such as barbiturateīenzodiazepines are sedative-hypnotic drugs that cause central nervous system and respiratory depression.Adult patients should receive doses of 0.2 mg every 1-2 minutes until arousable.The risk of seizure following the administration of flumazenil in the literature is very low in appropriately selected patients.Flumazenil is indicated for the reversal of benzodiazepine overdose. ![]()
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